Kip3-ing kinetochores clustered
نویسندگان
چکیده
منابع مشابه
Kip3-ing kinetochores clustered.
Metaphase is the brief and highly conspicuous period during cell division where chromosomes become positioned at the spindle equator through the process of " congression ". it is generally believed that congression promotes accurate chromosome segregation during anaphase, and this logic has driven research over several decades to identify the underlying mechanisms. Recent studies have demonstra...
متن کاملKip3 clusters kinetochores.
During mitosis chromosome segregation relies on the action of microtubules within the mitotic spindle. Each chromosome is attached to spindle microtubules via its sister kinetochores, the proteinacious complexes found at opposite sides of its centromere.1 The subset of microtubules that becomes attached to the kinetochores is referred to as kinetochore microtubules (kMTs). While each kinetochor...
متن کاملKip3, the yeast kinesin-8, is required for clustering of kinetochores at metaphase.
In Saccharomyces cerevisiae, chromosome congression clusters kinetochores on either side of the spindle equator at metaphase. Many organisms require one or more kinesin-8 molecular motors to achieve chromosome alignment. The yeast kinesin-8, Kip3, has been well studied in vitro but a role in chromosome congression has not been reported. We investigated Kip3's role in this process using semi-aut...
متن کاملKinetochores
Not to be confused with1⁄4 centrosomes. But it’s OK to confuse them with centromeres. The centromere is the chromosomal domain where the kinetochore is assembled. Genetically speaking, the centromere is the locus necessary to segregate chromosomes. In many species, the centromere is also defined cytologically as the primary constriction visible on condensed chromosomes (the intersection point o...
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The aim of this paper is to clearly demonstrate the importance of finding a good balance between genetic search and local search in the implementation of hybrid evolutionary multi-criterion optimization (EMO) algorithms. We first modify the local search part of an existing multi-objective genetic local search (MOGLS) algorithm. In the modified MOGLS algorithm, the computation time spent by loca...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2010
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.9.13.12274